Radiotherapy-assisted tumor selective metronomic oral chemotherapy

Tumor priming using metronomic chemotherapy with neovasculature-targeted, nanoparticulate paclitaxel.

Normalization of the tumor microenvironment is a promising approach to render conventional chemotherapy more effective. Although passively targeted drug nanocarriers have been investigated to this end, actively targeted tumor priming remains to be explored. In this work, we demonstrate an effective tumor priming strategy using metronomic application of nanoparticles actively targeted to tumor n...

Antiangiogenic metronomic chemotherapy.

Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com Most of the phase I–II clinical studies performed up to now used ‘metronomic-like’ schedules of cytostatic agents, often administered using weekly schedules of vinca alkaloids, taxanes, anthracyclines or alkylating agents resulting, however, in high dose-density treatments. A rational ide...

Metronomic chemotherapy beyond misconceptions.

Metronomic Chemotherapy Roberta

Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com Most of the phase I–II clinical studies performed up to now used ‘metronomic-like’ schedules of cytostatic agents, often administered using weekly schedules of vinca alkaloids, taxanes, anthracyclines or alkylating agents resulting, however, in high dose-density treatments. A rational ide...

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy

Oral mucositis represents a major non-hematologic complication of cytotoxic chemotherapy and radiotherapy associated with significant morbidity; pain, odynodysphagia, dysgeusia, and subsequent dehydration and malnutrition reduce the quality of life of affected patients. In addition, oral mucositis represents a significant risk factor for systemic infections, particularly in neutropenic patients...